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Wednesday, May 13, 2020 | History

2 edition of Identification of interacting proteins to the K15 protein of Kaposi"s sarcoma-associated herpesvirus. found in the catalog.

Identification of interacting proteins to the K15 protein of Kaposi"s sarcoma-associated herpesvirus.

Caesar Lim

Identification of interacting proteins to the K15 protein of Kaposi"s sarcoma-associated herpesvirus.

by Caesar Lim

  • 233 Want to read
  • 6 Currently reading

Published .
Written in English


About the Edition

Kaposi"s sarcoma-associated herpesvirus, also known as human herpervirus 8, is closely associated with several cancers including Kaposi"s sarcoma, primary effusion lymphoma and multicentric Castleman"s disease. The rightmost end of the KSHV genome encodes a protein, K15, with multiple membrane-spanning segments and an intracellular carboxy-terminal tail that contains several conserved motifs with the potential to recruit interaction domains (i.e. SH2, SH3, TRAF) of host cell proteins. K15 has been implicated in downregulating B cell receptor (BCR) signaling through its conserved motifs, and may thereby play a role in maintaining viral latency and/or preventing apoptosis of the infected B cells. However, K15"s mode of action is largely unknown. We have used mass spectrometry, domain and peptide arrays, and surface plasmon resonance, to identify binding partners to the conserved proline-rich sequence (PPLP) in the K15 cytoplasmic tail. We show that the PPLP motif selectively binds the third SH3 domain of an endocytic adaptor protein, Intersectin 2 (ITSN2). This interaction can be observed both in vitro and in cells, where K15 and ITSN2 co-localize to discrete compartments within the B cell. The ability of K15 to associate with ITSN2 suggests a new role for the K15 viral protein in intracellular protein trafficking.

The Physical Object
Pagination77 leaves.
Number of Pages77
ID Numbers
Open LibraryOL21218875M
ISBN 109780494273593


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Identification of interacting proteins to the K15 protein of Kaposi"s sarcoma-associated herpesvirus by Caesar Lim Download PDF EPUB FB2